AAGP® tested cell lines
ProtoKinetix has gone through more than a decade of international testing to measure AAGP®’s capabilities to address common challenges faced by researchers in regenerative medicine. In partnership with some of the world’s top scientists, we have tested the following cell lines to better understand AAGP®’s performance under stress.
Tested cell lines
Keratinocytes (human)
Stress conditions:
- Normal growth conditions
AAGP® concentration used: 1, 2 and 5 mg/ml
Adult fibroblasts (human)
Stress conditions:
- Oxidation (H202)
- Low temperature (15°C)
- Varying pH (5.3-10.5)
- Radiation (UVC)
AAGP® concentration used: 1, 5 and 15 mg/ml
Neonatal fibroblasts (human)
Stress conditions
- Low temperature (22°C, 15°C and 4°C)
- Radiation (UVC)
AAGP® concentration used: 1, 5 and 15 mg/ml
Blood platelets (human)
Stress conditions
- Low temperature (-3°C and 3°C)
AAGP® concentration used: 1 and 4 mg/ml
Umbilical cord blood (human)
Stress conditions
- Cryopreservation (-196°C)
AAGP® concentration used – 1 and 4 mg/ml
Neural embryonic stem cells (mouse and human)
Stress conditions
- Cryopreservation (-80°C)
- Low temperature (4°C)
AAGP® concentration used: 1, 2.5 and 5 mg/ml
Hela (cancer) cells
Stress conditions
- Radiation (UVC and UVA)
- Inflammation
AAGP® concentration used: 5 mg/ml and 8.6 mM
Adult primary fibroblasts (human)
Stress conditions
- Radiation (UVC)
AAGP® concentration used: 5 mg/ml
Islet cells (mouse)
Stress conditions
- In vivo
AAGP® concentration used: [X] mg/ml (missing)
Kidney (KB and Vero) cells
Stress Conditions
- Stress condition 1
- Stress condition 2
- Stress condition 3
AAGP® concentration used: [X] mg/ml (missing)
Heart cells (cardiac myocytes)
Stress Conditions
- Stress condition 1
- Stress condition 2
- Stress condition 3
AAGP® concentration used: [X] mg/ml (missing)
Liver cells (hepatocytes)
Stress Conditions
- Stress condition 1
- Stress condition 2
- Stress condition 3
AAGP® concentration used: [X] mg/ml (missing)
Dose, toxicity and pH tests
Our dose and toxicity tests were performed on human keratinocytes under normal cell conditions to test AAGP®’s protective properties.
Bioactivity assays
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ProtoKinetix, Inc.